• Article  

      Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and circulating ACE levels are not associated with outcome in critically ill septic patients 

      Tsantes, Argirio E.; Tsangaris, I.; Kopterides, Petros; Nikolopoulos, Georgios K.; Kalamara, Eleni; Antonakos, Georgios; Kapsimali, Violetta; Gialeraki, Argiri; Dimopoulou, Ioanna; Orfanos, S.; Dima, Kleanthi; Travlou, Anthi S.; Armaganidis, Apostolos (2012)
      Background: In critically ill patients independent studies have shown contradictory findings regarding the prognostic significance of the D/D genotype of the I/D angiotensin converting enzyme (ACE) polymorphism. The study ...
    • Article  

      Assessing the secular trends in the transmission of HIV in Greece 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Masgala, Aikaterini; Paraskeva, D. (2005)
      Objective: To evaluate the current trends in HIV transmission in Greece. Methods: A retrospective study of HIV infected individuals reported to the Hellenic Center for Infectious Diseases Control (HCIDC) was conducted. ...
    • Article  

      The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsangaris, I.; Tsiara, Chrissa G.; Kopterides, Petros; Vaiopoulos, A.; Kapsimali, Violetta; Bonovas, Stefanos; Tsantes, Argirio E. (2014)
      Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ...
    • Article  

      Association between the plasminogen activator inhibitor-1 4G/5G gene polymorphism and ischemic stroke; A meta-analysis. 

      Nikolopoulos, Georgios K.; Tsantes, Argirio E.; Bagos, Pantelis G.; Tsiara, Chrissa G.; Mantzios, Georgios P.; Kapsimali, Violetta; Pappa, Vassiliki; Travlou, Anthi S. (2006)
    • Article  

      Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Rapti, E.; Mantzios, Georgios P.; Kapsimali, Violetta; Travlou, Anthi S. (2007)
      The effect of the 675 insertion/deletion (4G/5G) polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene on the risk of venous thromboembolism (VTE) remains controversial. In this study, we performed a meta-analysis ...
    • Article  

      Cost-effectiveness of leucoreduction for prevention of febrile non-haemolytic transfusion reactions 

      Tsantes, Argirio E.; Kyriakou, Elias; Nikolopoulos, Georgios K.; Stylos, D.; Sidhom, M.; Bonovas, Stefanos; Douramani, Panagiota; Kalantzis, Dimitrios; Kokoris, Styliani; Valsami, S.; Stamoulis, K.; Politou, M.; Foudoulaki-Paparizos, Leontini (2014)
      Background. The cost-effectiveness of universal leucoreduction of blood components remains unclear. When using leucoreduced red blood cells, the decrease in the rate of febrile non-haemolytic transfusion reactions (FNHTR) ...
    • Article  

      Direct evidence for normalization of platelet function resulting from platelet count reduction in essential thrombocythemia 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Tsirigotis, P.; Zoi, K.; Zomas, A.; Kapsimali, Violetta; Kopterides, Petros; Chondropoulos, Spyros; Dervenoulas, John; Mantzios, Georgios P. (2011)
      Essential thrombocythemia is characterized by persistent elevation and functional disturbances of platelets. Both the platelet function analyzer-100 (PFA-100) collagen-epinephrine (CEPI) cartridge and aggregometry with ...
    • Article  

      Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome 

      Tsantes, Argirio E.; Kopterides, Petros; Bonovas, Stefanos; Bagos, Pantelis G.; Antonakos, Georgios; Nikolopoulos, Georgios K.; Gialeraki, Argiri; Kapsimali, Violetta; Kyriakou, Elias; Kokoris, Styliani; Dima, Kleanthi; Armaganidis, Apostolos; Tsangaris, I. (2013)
      Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains ...
    • Article  

      The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis 

      Tsantes, Argirio E.; Tsangaris, I.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Kopterides, Petros; Antonakos, Georgios; Dimopoulou, Ioanna; Vrioni, G.; Kapsimali, Violetta; Dima, Kleanthi; Armaganidis, Apostolos; Travlou, Anthi S. (2010)
      Background. There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis ...
    • Article  

      The effect of plasma homocysteine levels on clinical outcomes of patients with acute lung injury/acute respiratory distress syndrome 

      Tsangaris, I.; Tsantes, Argirio E.; Bagos, Pantelis G.; Nikolopoulos, Georgios K.; Kroupis, C.; Kopterides, Petros; Dimopoulou, Ioanna; Orfanos, S.; Kardoulaki, A.; Chideriotis, S.; Travlou, Anthi S.; Armaganidis, Apostolos (2009)
      Background: Several reports have shown that homocysteine promotes thrombosis by disturbing the procoagulant-anticoagulant balance, whereas alterations in coagulation and fibrinolysis have been suggested as important ...
    • Article  

      The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos; Kopterides, Petros; Vaiopoulos, G. (2008)
      Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma ...
    • Article  

      Epidemiology of aids defining conditions in Greece 

      Masgala, Aikaterini; Nikolopoulos, Georgios K.; Tsantes, Argirio E.; Paraskeva, D. (2004)
      Objective: To examine the secular trends of all AIDS opportunistic infections to occur first (Ols) in Greece, by year, by gender and by mode of transmission. Methods: The study included all AIDS defining conditions reported ...
    • Article  

      HIV/AIDS: Recent advances in antiretroviral agents 

      Nikolopoulos, Georgios K.; Bonovas, Stefanos; Tsantes, Argirio E.; Sitaras, N. M. (2009)
      Despite the considerable progress in antiretroviral therapy, the eradication of HIV-1 remains unfeasible. Therefore, novel agents are under investigation. The aim of this review is to summarize the conventional compounds, ...
    • Article  

      Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis 

      Nikolopoulos, Georgios K.; Tsantes, Argirio E.; Bagos, Pantelis G.; Travlou, Anthi S.; Vaiopoulos, G. (2007)
      Introduction: Platelet adhesion to fibrillar collagen via the membrane glycoprotein (GP) Ia/IIa (α2β1), is a crucial event in the pathogenesis of arterial occlusive disorders. The C807T single nucleotide polymorphism of ...
    • Article  

      Laboratory Assessment of the Anticoagulant Activity of Dabigatran 

      Kyriakou, Elias; Ikonomidis, Ignatios; Stylos, D.; Bonovas, Stefanos; Papadakis, I.; Nikolopoulos, Georgios K.; Kokoris, Styliani; Kalantzis, Dimitrios; Economopoulou, Christine; Kopterides, Petros; Lekakis, John; Tsantes, Argirio E. (2015)
      Background: Our aim was to identify laboratory assays in order to assess the anticoagulant effects of dabigatran etexilate (DE). Methods: Twenty patients with nonvalvular atrial fibrillation treated on DE (110 mg per os ...
    • Article  

      Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysis 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Vaiopoulos, G.; Travlou, Anthi S. (2007)
      Background: The platelet-collagen receptor, glycoprotein (GP) la/lla plays a crucial role in the adhesion of platelets to fibrillar collagen, an event contributing to the pathogenesis of thrombosis. The C807T polymorphism ...
    • Article  

      Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of ischemic stroke: A meta-analysis 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsiara, Chrissa G.; Kapsimali, Violetta; Travlou, Anthi S.; Vaiopoulos, G. (2007)
      This study investigated the hypothesis that the insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor type-1 gene affects the risk for ischemic stroke, since results concerning this association ...
    • Article  

      Reference ranges of thromboelastometry in healthy full-term and pre-term neonates 

      Sokou, R.; Foudoulaki-Paparizos, Leontini; Lytras, Theodoros; Konstantinidi, Aikaterini; Theodoraki, M.; Lambadaridis, Ioannis; Gounaris, Antonis; Valsami, S.; Politou, M.; Gialeraki, Argiri; Nikolopoulos, Georgios K.; Iacovidou, Nicoletta; Bonovas, Stefanos; Tsantes, Argirio E. (2017)
      Rotational thromboelastometry (ROTEM) is an attractive method for rapid evaluation of hemostasis in neonates. Currently, no reference values exist for ROTEM assays in full-term and pre-term neonates. Our aim was to establish ...
    • Article  

      Surveillance data on paediatric HIV infection and AIDS in Greece. 

      Nikolopoulos, Georgios K.; Konte, Vasileia; Masgala, Aikaterini; Eleni, E.; Tsantes, Argirio E.; Paraskeva, D. (2004)
      In Greece, HIV/AIDS surveillance is conducted by the Hellenic Centre for Infectious Diseases Control. The AIDS case reporting system was implemented in 1984, followed by notification of HIV infections in 1998. This article ...